Kalluri Jhansi R, West Julianna, Akkaraju Giridhar R, Canham Leigh T, Coffer Jeffery L
Department of Chemistry and Biochemistry and Department of Biology, Texas Christian University, Fort Worth, Texas 76129, United States.
Nanoscale Physics, Chemistry, and Engineering Research Laboratory, University of Birmingham, Birmingham B15 2TT, U.K.
ACS Omega. 2019 May 9;4(5):8359-8364. doi: 10.1021/acsomega.9b00127. eCollection 2019 May 31.
The properties of nanostructured plant-derived porous silicon (pSi) microparticles as potential candidates to increase the bioavailability of plant extracts possessing anti-inflammatory activity are described in this work. pSi drug carriers were fabricated using an eco-friendly route from the silicon accumulator plant bamboo (tabasheer) powder by magnesiothermic reduction of plant-derived silica and loaded with ethanolic extracts of , another silicon accumulator plant rich in polyphenolic compounds. The anti-inflammatory properties of the active therapeutics present in this extract were measured by sensitive luciferase reporter assays; this active extract was subsequently loaded and released from the pSi matrix, with a clear inhibition of the activity of the inflammatory signaling protein NF-κB over a period of hours in a sustained manner. Our results showed that after loading the extracts of into pSi microparticles derived from tabasheer, enhanced anti-inflammatory activity was observed owing to enhanced solubility of the extract.
本文描述了纳米结构的植物源多孔硅（pSi）微粒作为增加具有抗炎活性的植物提取物生物利用度的潜在候选物的特性。pSi药物载体是通过一种环保途径，利用硅蓄积植物竹子（竹黄）粉末，通过对植物源二氧化硅进行镁热还原制备而成，并负载了另一种富含多酚化合物的硅蓄积植物的乙醇提取物。通过灵敏的荧光素酶报告基因检测法测定了该提取物中活性治疗剂的抗炎特性；随后，这种活性提取物被负载到pSi基质中并从其中释放出来，在数小时内以持续的方式明显抑制了炎症信号蛋白NF-κB的活性。我们的结果表明，将提取物负载到源自竹黄的pSi微粒中后，由于提取物溶解度的提高，观察到了增强的抗炎活性。
