Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
Parkinsonism Relat Disord. 2011 Jan;17(1):58-60. doi: 10.1016/j.parkreldis.2010.10.002. Epub 2010 Oct 25.
The aim of this retrospective study was to assess the presence of a possible association between handedness and the side of symptom dominance in 963 patients with Parkinson's disease (PD). In only 287 patients the hand dominance was registered. Out of 254 right-handed patients, 158 (62%) had a right-side dominance of PD symptoms, while 96 patients (38%) had left-lateralized symptom dominance (p < 0.001). For the 33 left-handed subjects, 18 (55%) had left- and 15 (45%) had right-sided symptom dominance (p = 0.602). Right-handedness thus appeared to be associated with right-sided dominance of PD symptoms, while the group of left-handed patients was too small to draw conclusions from. Possible explanations are discussed.
本回顾性研究旨在评估 963 例帕金森病（PD）患者中利手与症状优势侧之间可能存在的关联。在仅 287 例患者中记录了手的优势性。在 254 名右利手患者中，158 名（62%）PD 症状有右侧优势，而 96 名患者（38%）有左侧症状优势（p<0.001）。对于 33 名左利手患者，18 名（55%）有左侧症状优势，15 名（45%）有右侧症状优势（p=0.602）。因此，右利手似乎与 PD 症状的右侧优势有关，而左利手患者的人数太少，无法得出结论。讨论了可能的解释。
