Department of Neurology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, China.
Department of Neurology, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, China.
Med Clin (Barc). 2014 Feb 20;142(4):141-4. doi: 10.1016/j.medcli.2012.11.028. Epub 2013 Jan 24.
To investigate the association between handedness and the side of symptom dominance in Parkinson's disease (PD).
One hundred and forty-six PD patients with symmetric symptoms (92 males and 54 females), aged 64.3 ± 9.1 years old, from a series of 247 PD patients were assessed for handedness and clinical features. The severity of PD was scored by unified Parkinson's disease rating scale (UPDRS) and Hoehn-Yahr staging on the "ON" state.
Of 134 right-handed patients (91.8%), 83 (61.7%) had an initial onset on the right side (P=0.008), while of 12 left-handed patients (8.2%), 9 (75.0%) had an initial onset on the left side (P=0.013). Out of right-handed patients, 103 (76.9%) had the right-side dominance of PD symptoms (P<0.001). Among the left-handed subjects, 7 patients (58.3%) had left-sided and 5 patients (41.7%) had right-sided symptom dominance (P=0.564). In general, dominant side of symptoms was in accordance with handedness (P=0.008). In right-handed patients, rest tremor was the most common initial symptom (P<0.001), while rest tremor and rigidity-bradykinesia were initial symptoms in left-handed patients (P=0.366).
PD symptoms emerge more often on the dominant hand-side, and the dominant side of symptoms is in accordance with handedness.
研究利手与帕金森病（PD）症状优势侧之间的关系。
对 247 例 PD 患者系列中的 146 例双侧症状对称（92 例男性，54 例女性）、年龄 64.3±9.1 岁的 PD 患者进行利手和临床特征评估。PD 的严重程度通过统一帕金森病评定量表（UPDRS）和 Hoehn-Yahr 分期在“ON”状态下进行评分。
在 134 名右利手患者（91.8%）中，83 名（61.7%）的初始发病侧为右侧（P=0.008），而在 12 名左利手患者（8.2%）中，9 名（75.0%）的初始发病侧为左侧（P=0.013）。在右利手患者中，103 名（76.9%）有 PD 症状的右侧优势（P<0.001）。在左利手患者中，7 名（58.3%）有左侧症状优势，5 名（41.7%）有右侧症状优势（P=0.564）。总的来说，症状的优势侧与利手一致（P=0.008）。在右利手患者中，静止性震颤是最常见的初始症状（P<0.001），而在左利手患者中，静止性震颤和僵硬-运动迟缓是初始症状（P=0.366）。
PD 症状更常出现在优势手侧，且症状的优势侧与利手一致。
