韩国感染相关癌症的人群归因分数。

Population attributable fraction of infection-related cancers in Korea.

机构信息

Cancer Epidemiology Branch, Division of Cancer Epidemiology and Management.

Cancer Registration and Statistics Branch, Division of Cancer Registration and Surveillance, National Cancer Center, Goyang-si, Korea.

出版信息

Ann Oncol. 2011 Jun;22(6):1435-1442. doi: 10.1093/annonc/mdq592. Epub 2010 Oct 25.

DOI:10.1093/annonc/mdq592

PMID:20974652

Abstract

BACKGROUND

A number of infectious agents have been classified as human carcinogens. The purpose of the current study was to provide an evidence-based assessment of the burden of infection-related cancers in the Korean population.

MATERIALS AND METHODS

The population attributable fraction was calculated using infection prevalence data from 1990 or earlier, relative risk estimates from meta-analyses using mainly Korean studies and national data on cancer incidence and mortality for the year 2007.

RESULTS

The fractions of all cancers attributable to infection were 25.1% and 16.8% for cancer incidence in men and women, and 25.8% and 22.7% of cancer mortality in men and women, respectively. Among infection-related cancers, Helicobacter pylori was responsible for 56.5% of cases and 45.1% of deaths, followed by hepatitis B virus (HBV) (23.9% of cases and 37.5% of deaths) and human papillomavirus (HPV) (11.3% of cases and 6% of deaths) and then by hepatitis C virus (HCV) (6% of cases and 9% of deaths). Over 97% of infection-related cancers were attributable to infection with H. pylori, HBV, HCV and HPV.

CONCLUSION

Up to one-quarter of cancer cases and deaths would be preventable through appropriate control of infectious agents in Korea.

摘要

背景

许多传染病原已被归类为人类致癌物。本研究的目的是对韩国人群中与感染相关的癌症负担进行基于证据的评估。

材料与方法

使用 1990 年或更早的感染流行数据、主要来自韩国研究的荟萃分析中的相对风险估计值以及 2007 年癌症发病率和死亡率的国家数据，计算人群归因分数。

结果

在男性和女性的癌症发病率中，归因于感染的所有癌症的比例分别为 25.1%和 16.8%，在男性和女性的癌症死亡率中，归因于感染的比例分别为 25.8%和 22.7%。在与感染相关的癌症中，幽门螺杆菌导致 56.5%的病例和 45.1%的死亡，其次是乙型肝炎病毒（HBV）（23.9%的病例和 37.5%的死亡）和人乳头瘤病毒（HPV）（11.3%的病例和 6%的死亡），然后是丙型肝炎病毒（HCV）（6%的病例和 9%的死亡）。超过 97%的与感染相关的癌症归因于幽门螺杆菌、HBV、HCV 和 HPV 的感染。