光照期光照强度对大鼠和小鼠松果体吲哚昼夜变化的影响。

Influence of intensity of illumination during the light period on diurnal variations of pineal indoles in rats and mice.

作者信息

Azuma H, Yamatodani A, Yagi A, Nishimura T, Wada H

机构信息

Department of Psychiatry, Faculty of Medicine, Osaka University, Japan.

出版信息

Neurosci Lett. 1990 Oct 30;119(1):15-8. doi: 10.1016/0304-3940(90)90744-t.

DOI:10.1016/0304-3940(90)90744-t

PMID:2097578

Abstract

The diurnal variations of pineal indoles in New-Zealand Black (NZB) mice and Wistar rats were determined by HPLC fluorometry. Pineal N-acetylserotonin (NAc5HT) in NZB mice showed a marked diurnal variation, but no melatonin (MLT) was detected at any time of day or night. The night-time increases of NAc5HT in NZB mice and MLT in Wistar rats were delayed about one hour in animals kept under illumination of high intensity (2000 lux) during the light period (12 h) compared with those in animals kept under illumination of low intensity (10 lux). These results suggest that the intensity of illumination during the light period affects the diurnal rhythms of pineal indoles in experimental animals.

摘要

采用高效液相色谱荧光法测定了新西兰黑鼠（NZB）和Wistar大鼠松果体吲哚的昼夜变化。NZB小鼠的松果体N-乙酰血清素（NAc5HT）呈现明显的昼夜变化，但在白天或夜晚的任何时间均未检测到褪黑素（MLT）。与在低强度光照（10勒克斯）下饲养的动物相比，在光照期（12小时）处于高强度光照（2000勒克斯）下饲养的动物，NZB小鼠夜间NAc5HT的增加和Wistar大鼠夜间MLT的增加均延迟约1小时。这些结果表明，光照期的光照强度会影响实验动物松果体吲哚的昼夜节律。