Kelly Caleb, Gangur Venu
Nutritional Immunology Program, Food Allergy and Immunology Laboratory, Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824, USA.
J Allergy (Cairo). 2009;2009:159845. doi: 10.1155/2009/159845. Epub 2009 Jul 2.
Food allergies are potentially fatal immune-mediated disorders that are growing globally. The relationship between sex and food allergy remains incompletely understood. Here we tested the hypothesis that, should sex influence the clinical response to food allergens, this would be reflected by a sex disparity in published studies of food allergy. We performed a systematic search of the PubMed literature for IgE-mediated allergy to 11 allergenic foods of international regulatory importance. No date restriction was used and only articles in English were considered. Of the 4744 articles retrieved, 591 met the inclusion criteria representing 17528 subjects with food allergies. Whereas among children with food allergies, 64.35% were males and 35.65% were females (male/female ratio, 1.80), among adults 34.82% were males and 65.18% were females (male/female ratio, 0.53). Consequently, these data argue that there is need for further investigation to define the role of sex in the pathogenesis of food allergy.
食物过敏是一种潜在致命的免疫介导性疾病，在全球范围内呈上升趋势。性别与食物过敏之间的关系仍未完全明确。在此，我们检验了这样一个假设：如果性别会影响对食物过敏原的临床反应，那么这将在已发表的食物过敏研究中的性别差异上有所体现。我们对PubMed文献进行了系统检索，以查找对11种具有国际监管重要性的致敏食物的IgE介导的过敏情况。未设置日期限制，仅纳入英文文章。在检索到的4744篇文章中，591篇符合纳入标准，代表了17528名食物过敏受试者。在食物过敏儿童中，男性占64.35%，女性占35.65%（男/女比例为1.80）；而在成年人中，男性占34.82%，女性占65.18%（男/女比例为0.53）。因此，这些数据表明有必要进一步研究以明确性别在食物过敏发病机制中的作用。
