Sood A, Ford E S, Camargo C A
Division of Pulmonary and Critical Care Medicine, Southern Illinois University School of Medicine, 701 North First Street, Room D434, P O Box 19636, Springfield, IL 62794-9636, USA.
Thorax. 2006 Apr;61(4):300-5. doi: 10.1136/thx.2004.031468. Epub 2006 Mar 15.
Leptin, a pro-inflammatory cytokine produced by adipose tissue, has previously been shown to be associated with asthma in children. We hypothesised that high serum leptin concentrations would also be associated with asthma in adults.
The Third National Health and Nutrition Examination Survey is a cross sectional study that included fasting serum leptin concentrations and self-report of doctor diagnosed asthma. Data were analysed using multivariable logistic regression analysis.
Of 5876 participants, those with current asthma had a higher mean unadjusted leptin concentration than those who had never had asthma (geometric mean (SE) 9.2 (0.6) microg/l v 7.6 (0.2) microg/l; p = 0.02). After adjustment for triceps skinfold thickness and other covariates, the association between leptin and asthma appeared stronger in women than in men, and in premenopausal women than in postmenopausal women. Body mass index (BMI) was also associated with current asthma in women, but this association was not significantly affected by adjustment for leptin concentrations.
The results of this large population based study support the hypothesis that leptin is associated with asthma in women. In addition, while BMI also is related to asthma in women, this study does not support the suggestion that leptin contributes significantly to this association.
瘦素是一种由脂肪组织产生的促炎细胞因子，此前已证明其与儿童哮喘有关。我们推测高血清瘦素浓度也与成人哮喘有关。
第三次全国健康和营养检查调查是一项横断面研究，包括空腹血清瘦素浓度和医生诊断哮喘的自我报告。使用多变量逻辑回归分析对数据进行分析。
在5876名参与者中，当前患有哮喘的参与者未经调整的瘦素平均浓度高于从未患过哮喘的参与者（几何平均数（标准误）9.2（0.6）μg/L对7.6（0.2）μg/L；p = 0.02）。在调整三头肌皮褶厚度和其他协变量后，瘦素与哮喘之间的关联在女性中似乎比在男性中更强，在绝经前女性中比在绝经后女性中更强。体重指数（BMI）也与女性当前的哮喘有关，但这种关联在调整瘦素浓度后没有受到显著影响。
这项基于大量人群的研究结果支持瘦素与女性哮喘有关的假设。此外，虽然BMI也与女性哮喘有关，但本研究不支持瘦素对这种关联有显著贡献的观点。
