Mühlenstedt D, Hanker J, Schneider H P
Arch Gynakol. 1978 Jul 19;225(3):237-45. doi: 10.1007/BF00667206.
LH-RH tests of hypothalamo-pituitary gonadotropinfunction were performed in 26 patients with pituitary adenomata before and after prolactin suppression and/or surgical treatment. Various degrees of galactorrhea together with menstrual disorders were the key symptoms in all patients. There was a significant association of elevated prolactin levels with impaired LH-responses. Seven patients have undergone transspenoidal dissection of the pituitary adenoma and in five of them the pituitary LH-response reverted to normal (R2) after surgery. Nine of 15 amenorrhoic patients had a recurrence of menstrual cyclicity, partly biphasic within 3 months and a normalized LH-response after Bromocriptin therapy. 19 of our patients were desirous of pregnancy. Five pregnancies were confirmed within 4 months of treatment.
对26例垂体腺瘤患者在催乳素抑制和/或手术治疗前后进行了下丘脑-垂体促性腺激素功能的促黄体生成素释放激素（LH-RH）试验。所有患者的主要症状为不同程度的溢乳伴月经紊乱。催乳素水平升高与促黄体生成素（LH）反应受损之间存在显著关联。7例患者接受了经蝶窦垂体腺瘤切除术，其中5例术后垂体LH反应恢复正常（R2）。15例闭经患者中有9例月经周期恢复，部分在3个月内呈双相性，溴隐亭治疗后LH反应恢复正常。我们的19例患者渴望怀孕。治疗后4个月内确诊5例妊娠。
