[Effect of biguanides on the indicators of thrombelastography and the level of lactic acid in diabetes mellitus].

The authors analyze the results of examinations of 232 patients with diabetes mellitus; 48 of these suffering from type I diabetes and 64 from type II diabetes were treated with biguanides. Thromboelastograms were recorded in the presence of hyperglycemia and repeatedly during stable compensation of diabetes, and their values were analyzed with due consideration for therapy administered. Since biguanides are known to induce lactate acidosis, blood serum lactic acid levels were measured when the patients were hospitalized, in the presence of hyperglycemia, and then after a standard exercise test (to detect latent acidosis). When stable compensation of diabetes mellitus was achieved, the examination scheme described before was repeated, i. e. lactic acid measurements before and after exercise test, with due consideration for the therapy administered. Biguanides were found to be conducive to normalization of thrombelastogram values, not elevating the blood serum content of lactic acid even after exercise test.