Department of Pharmacology and Toxicology and Neuroscience Program, B307 Life Sciences Building, Michigan State University, East Lansing, MI 48824, USA.
Reprod Toxicol. 2011 Feb;31(2):134-43. doi: 10.1016/j.reprotox.2010.10.009. Epub 2010 Oct 25.
Reproductive and developmental toxicities of zinc supplementation in F(0) rats and F(1) progeny were examined. Rats were treated by gavaging with zinc chloride (ZnCl(2)) at 0.0, 7.5, 15 and 30 mg/kg-d. ZnCl(2) treatment was associated with deficient energy imbalances, reduced number of live pups/litter, decreased live birth index, increased mortality and increased fetal resorption. Changes in serum clinical chemistry and hematologic parameters were sex-related. In F(0) females, ZnCl(2) was associated with increased liver/body weight ratios, reduced creatinine and reduced alkaline phosphatase concentrations. In F(0) males, ZnCl(2) significantly increased relative liver weight and elevated γ-GGT. In addition, at birth, F(1) males exhibited, a significant (p<0.05) increase in anogenital distance, whereas ZnCl(2) hastened the time of eye opening and incisor eruption in males and females. These results indicate that excess ZnCl(2) supplementation before and during pregnancy and during lactation could pose some health risk concerns to pregnant mothers and their offspring.
研究了补锌对 F(0)大鼠及其 F(1)后代的生殖和发育毒性。大鼠通过灌胃给予氯化锌（ZnCl(2)），剂量分别为 0.0、7.5、15 和 30mg/kg-d。ZnCl(2)处理与能量失衡、活产仔数/窝减少、活产指数降低、死亡率增加和胎儿吸收率增加有关。血清临床化学和血液学参数的变化与性别有关。在 F(0)雌性大鼠中，ZnCl(2)导致肝脏/体重比增加、肌酐减少和碱性磷酸酶浓度降低。在 F(0)雄性大鼠中，ZnCl(2)显著增加了相对肝脏重量并升高了γ-GGT。此外，在出生时，F(1)雄性大鼠的肛殖距离显著增加（p<0.05），而 ZnCl(2)加速了雄性和雌性大鼠的眼睛睁开和牙齿萌出时间。这些结果表明，妊娠前、妊娠期间和哺乳期过量补充 ZnCl(2)可能会对孕妇及其后代的健康造成一些风险。
