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大鼠子宫内膜着床期干细胞标志物表达增加：外源性锌和/或孕酮的促进作用

Increased stem cell marker expressions during the peri-implantation period in the rat endometrium: constructive role of exogenous zinc and/or progesterone.

作者信息

Sahin Cagdas, Dilsiz Ozlem Yilmaz, Demiray Sirin Bakti, Yeniel Ozgur, Ergenoglu Mete, Sezer Ebru Demirel, Oktem Gulperi, Goker Ege Nazan Tavmergen, Tavmergen Erol

机构信息

Department of Obstetrics and Gynecology, Tepecik Training and Research Hospital, 35170 Izmir, Turkey.

Department of Histology and Embryology, Medicine Faculty, Ege University, 35040 Izmir, Turkey.

出版信息

Biomed Res Int. 2014;2014:867131. doi: 10.1155/2014/867131. Epub 2014 May 26.

DOI:10.1155/2014/867131
PMID:24971353
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4058199/
Abstract

BACKGROUND

The aim of this study is to determine the effects of zinc and/or progesterone via the expression of α v β 5 integrins and Vitronectins and embryonic stem cell markers during the peri-implantation period.

METHODS

Four experimental groups were organized. All subjects were mated with males of the same strain to induce pregnancy; after 5 days, zinc and/or progesterone were administered. Blood levels of zinc and progesterone were determined on the sixth day and endometrial tissues were obtained in order to evaluate the immunohistochemical expression of integrins and embryonic stem cell markers.

RESULTS

The αvβ5 integrin and vitronectin expression increased in the zinc group compared with the control group and no difference in the progesterone group and zinc + progesterone group. Expression of Klf-4, Sox-2, and c-Myc was found to be increased in the zinc group compared to controls, while no difference was determined between the progesterone, zinc + progesterone, and control groups. Distinctively, expression of the embryonic stem cell marker Oct-4 was increased in all of the experimental groups.

CONCLUSIONS

Expression of α v β 5 integrin, vitronectin, and embryonic stem cell markers might be increased by the administration of zinc. Our results suggest that zinc could be useful in the induction of implantation rates.

摘要

背景

本研究的目的是通过在着床期表达αvβ5整合素、玻连蛋白和胚胎干细胞标志物来确定锌和/或孕酮的作用。

方法

组织了四个实验组。所有受试者与同品系雄性交配以诱导怀孕；5天后，给予锌和/或孕酮。在第6天测定锌和孕酮的血药浓度，并获取子宫内膜组织以评估整合素和胚胎干细胞标志物的免疫组化表达。

结果

与对照组相比，锌组中αvβ5整合素和玻连蛋白表达增加，孕酮组和锌+孕酮组无差异。与对照组相比，锌组中Klf-4、Sox-2和c-Myc的表达增加，而孕酮组、锌+孕酮组和对照组之间未发现差异。值得注意的是，所有实验组中胚胎干细胞标志物Oct-4的表达均增加。

结论

锌的给药可能会增加αvβ5整合素、玻连蛋白和胚胎干细胞标志物的表达。我们的结果表明，锌可能有助于提高着床率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d88/4058199/0eeac601688f/BMRI2014-867131.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d88/4058199/c5841a871ae2/BMRI2014-867131.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d88/4058199/3ecfdbb64ef4/BMRI2014-867131.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d88/4058199/ddb85fc7d5a2/BMRI2014-867131.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d88/4058199/00754cd04839/BMRI2014-867131.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d88/4058199/3822929f621b/BMRI2014-867131.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d88/4058199/0eeac601688f/BMRI2014-867131.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d88/4058199/c5841a871ae2/BMRI2014-867131.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d88/4058199/3ecfdbb64ef4/BMRI2014-867131.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d88/4058199/ddb85fc7d5a2/BMRI2014-867131.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d88/4058199/00754cd04839/BMRI2014-867131.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d88/4058199/3822929f621b/BMRI2014-867131.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d88/4058199/0eeac601688f/BMRI2014-867131.006.jpg

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