Chemek Marouane, Kadi Ammar, Al-Mahdawi Fatimah Kadhim Ibrahim, Potoroko Irina
Department of food and biotechnology, South Ural State University, Chelyabinsk, 454080, Russia.
College of Medicine, University of Diyala, Divala, Iraq.
Reprod Sci. 2024 Dec;31(12):3673-3687. doi: 10.1007/s43032-024-01638-0. Epub 2024 Jul 10.
Research into innovative non-pharmacological therapeutic routes via the utilization of natural elements like zinc (Zn) has been motivated by the discovery of new severe acute respiratory syndrome-related coronavirus 2 (SARS-COV2) variants and the ineffectiveness of certain vaccination treatments during COVID-19 pandemic. In addition, research on SARS-COV-2's viral cellular entry and infection mechanism has shown that it may seriously harm reproductive system cells and impair testicular function in young men and adolescents, which may lead to male infertility over time. In this context, we conducted a narrative review to give an overview of the data pertaining to Zn's critical role in testicular tissue, the therapeutic use of such micronutrients to enhance male fertility, as well as in the potential mitigation of COVID-19, with the ultimate goal of elucidating the hypothesis of the potential use of Zn supplements to prevent the possible harmful effects of SARS-COV2 infection on testis physiological function, and subsequently, on male fertility.
新型严重急性呼吸综合征相关冠状病毒2（SARS-COV2）变种的发现以及在新冠疫情期间某些疫苗治疗的无效性，促使人们通过利用锌（Zn）等天然元素来研究创新的非药物治疗途径。此外，对SARS-COV-2病毒细胞进入和感染机制的研究表明，它可能严重损害生殖系统细胞，并损害年轻男性和青少年的睾丸功能，随着时间的推移可能导致男性不育。在此背景下，我们进行了一项叙述性综述，以概述与锌在睾丸组织中的关键作用、此类微量营养素在提高男性生育能力方面的治疗用途以及在潜在缓解新冠疫情方面的数据，最终目的是阐明补充锌可能用于预防SARS-COV2感染对睾丸生理功能以及随后对男性生育能力可能产生的有害影响这一假设。
