Haemostasis Unit, Haematology Department, Addenbrooke's Hospital, Cambridge, United Kingdom.
Semin Thromb Hemost. 2010 Oct;36(7):712-22. doi: 10.1055/s-0030-1265288. Epub 2010 Oct 26.
The thromboelastography trace provides a graphical and numerical representation of the viscoelastic changes associated with fibrin polymerization. When used with whole blood, the shape of this trace is a composite of the effects of white and red cell content and composition, platelet number and function, fibrinogen concentration, as well as coagulation protein function and balance. The trace is also influenced by pharmacological agents such as anticoagulants, antiplatelet therapy, and coagulation factor supplementation. As such the main role of this technology has been as a point-of-care device to guide transfusion of blood components. Recently the technology has moved from the cardiac and hepatic surgical settings, where most of the early work was focused, into other areas of hemostatic monitoring. New applications for pharmaceutical monitoring and patient screening are being explored. This review gives a broad overview of the applications of the technology. In particular it considers the factors that most influence the characteristics of the trace, be they preanalytical, analytical, or clinical.
血栓弹力图描记法提供了与纤维蛋白聚合相关的粘弹性变化的图形和数值表示。当与全血一起使用时，该描记法的形状是白细胞和红细胞含量和组成、血小板数量和功能、纤维蛋白原浓度以及凝血蛋白功能和平衡的综合影响。该描记法还受到抗凝剂、抗血小板治疗和凝血因子补充等药物的影响。因此，这项技术的主要作用一直是作为一种床边设备来指导血液成分的输注。最近，该技术已经从心脏和肝脏外科手术环境（早期工作的重点）转移到其他止血监测领域。正在探索用于药物监测和患者筛选的新应用。这篇综述广泛概述了该技术的应用。特别是，它考虑了对描记法特征影响最大的因素，无论是分析前、分析中还是临床因素。
