Roelofse J A, van der Bijl P, Joubert J J, Breytenbach H S
S Afr Med J. 1986 Dec 20;70(13):801-2.
In a double-blind randomized study on 16 healthy individuals, two groups of subjects (8 in each group) received either midazolam (Dormicum; Roche) 0.1 mg/kg or placebo intravenously for conscious sedation during oral surgical procedures. Oxygen saturation of the blood was measured at different stages. Ten minutes after administration of the drug, the percentage oxygen saturation was significantly lower (P less than 0.05) in the midazolam group than in the placebo group.
在一项针对16名健康个体的双盲随机研究中，两组受试者（每组8人）在口腔外科手术期间接受静脉注射0.1毫克/千克咪达唑仑（多美康；罗氏公司）或安慰剂以进行清醒镇静。在不同阶段测量血液中的氧饱和度。给药十分钟后，咪达唑仑组的氧饱和度百分比显著低于安慰剂组（P小于0.05）。
