Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
Org Lett. 2010 Nov 19;12(22):5318-21. doi: 10.1021/ol102325f. Epub 2010 Oct 27.
A unique effect of styrene additive on product selectivity was observed for RuH(2)(CO)(PPh(3))(3)-catalyzed C-H arylation of acetophenone derivatives bearing two ortho C-H bonds. Without styrene, the C-H arylation with arylboronates gives diarylation products as the major products throughout the reaction, but the use of styrene as an additive switches the product selectivity and leads to selective formation of monoarylation products.
观察到苯乙烯添加剂对 RuH(2)(CO)(PPh(3))(3)催化的带有两个邻位 C-H 键的苯乙酮衍生物的 C-H 芳基化反应的产物选择性具有独特的影响。没有苯乙烯时，芳基硼酸酯的 C-H 芳基化反应在整个反应过程中主要得到二芳基化产物，但使用苯乙烯作为添加剂可改变产物选择性，导致单芳基化产物的选择性形成。
