Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Expert Rev Clin Immunol. 2010 Nov;6(6):939-55. doi: 10.1586/eci.10.68.
The widely used nonobese diabetic (NOD) mouse model of autoimmune (Type 1) diabetes mellitus shares multiple characteristics with the human disease, and studies employing this model continue to yield clinically relevant and important information. Here, we review some of the recent key findings obtained from NOD mouse investigations that have both advanced our understanding of disease pathogenesis and suggested new therapeutic targets and approaches. Areas discussed include antigen discovery, identification of genes and pathways contributing to disease susceptibility, development of strategies to image islet inflammation and the testing of therapeutics. We also review recent technical advances that, combined with an improved understanding of the NOD mouse model's limitations, should work to ensure its popularity, utility and relevance in the years ahead.
广为应用的非肥胖型糖尿病（NOD）小鼠模型是一种自身免疫性（1 型）糖尿病模型，与人类疾病有多种相似特征，应用这一模型的研究不断提供具有临床意义的重要信息。在此，我们综述了一些近期从 NOD 小鼠研究中得到的关键发现，这些发现不仅增进了我们对疾病发病机制的理解，还为治疗靶点和治疗方法提供了新的思路。讨论的内容包括抗原发现、鉴定与疾病易感性相关的基因和途径、开发胰岛炎症成像策略和治疗药物的检测。我们还综述了近期的技术进展，这些进展结合对 NOD 小鼠模型局限性的进一步认识，将确保其在未来几年的普及、应用和相关性。
