分子标记揭示的印度北部阿加瓦尔家族的群体结构
Population structure of Aggarwals of north India as revealed by molecular markers.
作者信息
Gupta Vipin, Khadgawat Rajesh, Ng Hon Keung Tony, Kumar Satish, Rao Vadlamudi Raghavendra, Sachdeva Mohinder Pal
机构信息
South Asia Network for Chronic Disease (SANCD), Public Health Foundation of India, New Delhi, India.
出版信息
Genet Test Mol Biomarkers. 2010 Dec;14(6):781-5. doi: 10.1089/gtmb.2010.0095. Epub 2010 Oct 28.
Abstract
Using molecular genetic data on Aggarwals (Vaish/Vysya), an endogamous population group of north India, we provide evidence of its homogeneous unstratified population structure. We found the mean average heterozygosity value of 0.33 for 14 single nucleotide polymorphisms belonging to four genes (TCF7L2-, HHEX-, KCNJ11-, and ADIPOQ-) in the Aggarwal population (sample of 184 individuals) and tried to evaluate the genomic efficiency of endogamy in this population with the help of clan-based stratified analysis. We concluded that the sociocultural identity of the endogamous population groups could act as a robust proxy maker for inferring their homogeneity and population structure in India, which is ideal also for population selection for future genome-wide association studies in the country.
摘要
利用印度北部内婚制群体阿加瓦尔人（瓦伊什/吠舍）的分子遗传学数据，我们证明了其同质的、未分层的群体结构。我们在阿加瓦尔人群体（184名个体的样本）中发现，属于四个基因（TCF7L2、HHEX、KCNJ11和ADIPOQ）的14个单核苷酸多态性的平均杂合度值为0.33，并试图借助基于氏族的分层分析来评估该群体内婚制的基因组效率。我们得出结论，内婚制群体的社会文化身份可以作为推断其在印度的同质性和群体结构的有力代理指标，这对于该国未来全基因组关联研究的群体选择也是理想的。
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