Siclari Valerie A, Qin Ling
Department of Orthopaedic Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
J Orthop Surg Res. 2010 Oct 27;5:78. doi: 10.1186/1749-799X-5-78.
Osteosarcoma is the most common type of solid bone cancer and the second leading cause of cancer-related death in pediatric patients. Many patients are not cured by the current osteosarcoma therapy consisting of combination chemotherapy along with surgery and thus new treatments are urgently needed. In the last decade, cancer stem cells have been identified in many tumors such as leukemia, brain, breast, head and neck, colon, skin, pancreatic, and prostate cancers and these cells are proposed to play major roles in drug resistance, tumor recurrence, and metastasis. Recent studies have shown evidence that osteosarcoma also possesses cancer stem cells. This review summarizes the current knowledge about the osteosarcoma cancer stem cell including the methods used for its isolation, its properties, and its potential as a new target for osteosarcoma treatment.
骨肉瘤是最常见的实体骨癌类型，也是儿科患者癌症相关死亡的第二大主要原因。目前由联合化疗以及手术组成的骨肉瘤治疗方案无法治愈许多患者，因此迫切需要新的治疗方法。在过去十年中，已在许多肿瘤中鉴定出癌症干细胞，如白血病、脑癌、乳腺癌、头颈癌、结肠癌、皮肤癌、胰腺癌和前列腺癌，并且这些细胞被认为在耐药性、肿瘤复发和转移中起主要作用。最近的研究已证明骨肉瘤也含有癌症干细胞。本综述总结了目前关于骨肉瘤癌症干细胞的知识，包括用于分离它的方法、它的特性以及它作为骨肉瘤治疗新靶点的潜力。
