Ren Jun-Hong, Han Xiu-Jie, Chen Xiu-Hua, Zhang Zheng, Li Jing
Department of Ultrasonography, Beijing Hospital, Ministry of Health, Beijing 100730, China.
Zhonghua Yi Xue Za Zhi. 2010 Jun 15;90(23):1602-5.
To apply the receiver operating characteristic (ROC) curves and QAS technology in exploring sensitive and feasible indices about the structure and function of heart and arterial stiffness so as to determine the optimal operating point (OOP) and evaluate its value of cardiovascular changes in hypertensive patients.
The parameters of arterial stiffness and heart function were measured and calculated in hypertensive patients (n = 167) and control (n = 165). The results were compared and critical values obtained by receiver operating characteristic (ROC) curves.
Interventricular septal thickness, posterior wall thickness of left ventricle, E/e and Tei of hypertensive group were significantly higher than those of control group (P < 0.05). In hypertensive group, the parameters of arterial stiffness including beta, and PWVbeta were significantly higher than those of control group (P < 0.05). The areas of under the ROC curves were 0.808, 0.843, 0.816, 0.827, 0.779 and 0.632. The sensitivity and specificity of detecting the cardiovascular changes of hypertension for interventricular septal thickness, posterior wall thickness of left ventricle, E/e, Tei, PWVbeta and beta were 78.6%/78.9%, 82.1%/84.2%, 67.9%/89.5%, 100%/52.6%, 82.1%/68.4% and 57.1%/63.2% respectively.
The arterial stiffness and heart dysfunction may result from hypertension. Arterial stiffness can be one of monitoring indices in early-stage damage of heart function.
应用受试者工作特征（ROC）曲线及QAS技术探讨反映心脏结构与功能及动脉僵硬度的敏感且可行的指标，以确定最佳工作点（OOP），并评估其在高血压患者心血管变化中的价值。
对高血压患者（n = 167）和对照组（n = 165）进行动脉僵硬度及心功能参数的测量与计算。比较结果并通过受试者工作特征（ROC）曲线获得临界值。
高血压组的室间隔厚度、左心室后壁厚度、E/e及Tei均显著高于对照组（P < 0.05）。高血压组的动脉僵硬度参数包括β及脉搏波传导速度β（PWVβ）均显著高于对照组（P < 0.05）。ROC曲线下面积分别为0.808、0.843、0.816、0.827、0.779和0.632。室间隔厚度、左心室后壁厚度、E/e、Tei、PWVβ及β检测高血压心血管变化的敏感性和特异性分别为78.6%/78.9%、82.1%/84.2%、67.9%/89.5%、100%/52.6%、82.1%/68.4%和57.1%/63.2%。
高血压可能导致动脉僵硬度增加及心脏功能障碍。动脉僵硬度可作为心脏功能早期损害的监测指标之一。
