Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114-2696, USA.
J Vasc Interv Radiol. 2010 Dec;21(12):1791-805; quiz 1806. doi: 10.1016/j.jvir.2010.08.009. Epub 2010 Oct 27.
Angiogenesis is a complex process critical for embryonic development and for survival. It is also a critical player in many pathologic processes, most notably in neoplasia. The cell signaling pathways involved in angiogenesis have become key targets for drug design, with more than 2,500 clinical trials currently under way. This review summarizes the essential features of angiogenesis and discusses therapeutic strategies that have been applied to specific diseases known to be associated with perturbation of normal angiogenic control.
血管生成是胚胎发育和生存所必需的复杂过程。它也是许多病理过程中的关键参与者，尤其是在肿瘤发生中。参与血管生成的细胞信号通路已成为药物设计的关键靶点，目前正在进行超过 2500 项临床试验。本文综述了血管生成的基本特征，并讨论了已应用于已知与正常血管生成控制失调相关的特定疾病的治疗策略。
