Renal Medicine, Southend University Hospital NHS Trust, Westcliff on Sea, Essex, UK.
Nephrol Dial Transplant. 2011 Feb;26(2):744-7. doi: 10.1093/ndt/gfq663. Epub 2010 Oct 27.
The widespread use of reporting estimated glomerular filtration rate (eGFR) alongside serum creatinine has led to a heightened appreciation of renal disease. However, creatinine is recognized as an insensitive marker of true GFR and therefore can lead to misdiagnosis of renal dysfunction in the absence of true pathology. We report the case of a 37-year-old male referred due to abnormal eGFR and creatinine in the absence of clinical signs, symptoms or other biochemical abnormalities of renal disease. Subsequent investigations based on a high index of suspicion for exogenous substance abuse led to a novel observation of significantly raised creatinine due to the presence of boldenone, an equine anabolic steroid commonly abused in body building.
由于同时报告估算肾小球滤过率(eGFR)和血清肌酐,人们对肾脏疾病的认识有了显著提高。然而,肌酐被认为是真正肾小球滤过率的不敏感标志物,因此在没有真正病理的情况下,可能会导致肾功能障碍的误诊。我们报告了一例 37 岁男性病例,其 eGFR 和肌酐异常,但无临床体征、症状或其他肾脏疾病的生化异常。根据对外源性物质滥用的高度怀疑,进行了后续检查,结果发现由于使用了一种常用于健美运动的马源性合成代谢类固醇——宝丹酮,导致肌酐显著升高。