Department of Epidemiology and International Health, International Clinical Research Center, National Center for Global Health and Medicine, Tokyo, Japan.
Am J Clin Nutr. 2010 Dec;92(6):1468-77. doi: 10.3945/ajcn.2010.29512. Epub 2010 Oct 27.
Refined carbohydrates have been suggested to deteriorate glucose metabolism; however, whether persons with elevated intakes of white rice, which is a major staple food for the Japanese, experience increased risk of developing type 2 diabetes remains unclear.
We prospectively investigated the association between white rice intake and risk of type 2 diabetes.
Participants were 25,666 men and 33,622 women aged 45-75 y who participated in the second survey of the Japan Public Health Center-based Prospective Study and who had no prior history of diabetes. We ascertained food intake by using a validated 147-item food-frequency questionnaire. Odds ratios of self-reported, physician-diagnosed type 2 diabetes over 5 y were estimated by using logistic regressions.
A total of 1103 new cases of type 2 diabetes were self-reported. There was a significant association between rice intake and an increased risk of type 2 diabetes in women; the multivariate-adjusted odds ratio for the highest compared with lowest quartiles of rice intake was 1.65 (95% CI: 1.06, 2.57; P for trend = 0.005). In men, the association was unclear, although there was a suggestion of a positive association in persons who were not engaged in strenuous physical activity (P for trend = 0.08).
Elevated intake of white rice is associated with an increased risk of type 2 diabetes in Japanese women. The finding that is suggestive of a positive association of rice intake in physically inactive men deserves further investigation.
精制碳水化合物被认为会恶化葡萄糖代谢；然而，摄入大量白米饭（日本人的主要主食）的人是否会增加患 2 型糖尿病的风险尚不清楚。
我们前瞻性地研究了白米饭摄入量与 2 型糖尿病风险之间的关系。
参与者为 25666 名男性和 33622 名年龄在 45-75 岁之间的女性，他们参加了日本公共卫生中心前瞻性研究的第二次调查，并且没有糖尿病的既往病史。我们通过使用经过验证的 147 项食物频率问卷来确定食物摄入量。使用逻辑回归估计 5 年内自我报告的、医生诊断的 2 型糖尿病的比值比。
共报告了 1103 例新的 2 型糖尿病病例。在女性中，米饭摄入量与 2 型糖尿病风险增加之间存在显著关联；与最低 quartiles 相比，最高 quartiles 的米饭摄入量的多变量调整比值比为 1.65（95%CI：1.06，2.57；P 趋势=0.005）。在男性中，这种关联不明确，尽管对于不进行剧烈体力活动的人，存在正相关的迹象（P 趋势=0.08）。
日本女性中，白米饭摄入量增加与 2 型糖尿病风险增加相关。提示白米饭摄入量与不活跃男性之间存在正相关的发现值得进一步研究。
