Getova D
Eksp Med Morfol. 1990;29(4):45-50.
The content of GABA in the following regions of the brain: cerebellum, left and right hemisphere was studied on white male rats. The determination was made by the method of Sutton and Simmonds (1974). One control and 7 experimental groups were investigated. All examined substances were administered intraperitoneally and the animals were decapitated at their peak activity. The effect of newly synthesized hydroxyl amine barbiturate HB-7, administered in several doses, was studied, comparing it with the action of pentobarbital (PB) and of phenobarbital (PB). A considerable increase in the content of barbiturates was established in the cerebellum of rats under the influence of the applied barbiturates while the content of GABA in both large hemispheres was less affected by the administered compounds. A conclusion is made that a single administration of barbiturates affects the content of GABA in some cerebral structures of the rat.
对雄性白鼠大脑以下区域（小脑、左右半球）的γ-氨基丁酸（GABA）含量进行了研究。采用萨顿和西蒙兹（1974年）的方法进行测定。研究了1个对照组和7个实验组。所有受试物质均通过腹腔注射给药，在动物活动高峰期将其断头处死。研究了新合成的羟胺巴比妥酸盐HB-7不同剂量的作用，并将其与戊巴比妥（PB）和苯巴比妥（PB）的作用进行比较。在所施用的巴比妥酸盐影响下，大鼠小脑中巴比妥酸盐含量显著增加，而两个大脑半球中GABA的含量受所施用化合物的影响较小。得出的结论是，单次施用巴比妥酸盐会影响大鼠某些脑结构中GABA的含量。
