Getova D, Georgiev V
Department of Experimental Pharmacology, Institute of Physiology, Bulgarian Academy of Sciences.
Acta Physiol Pharmacol Bulg. 1989;15(1):83-8.
The antihypoxic effect of the newly-synthesized hydroxylamine barbiturate HB-7, compared with the effects of phenobarbital and pentobarbital, was studied in experiments on albino mice, using the following models of hypoxia: hypobaric, anoxic, asphyctic and haemic. A dose-effect dependence was established when the survival of the mice was prolonged under the effects of the barbiturates tested, applying the asphyctic and haemic hypoxy tests. The latter two tests were also used to determine the average effective doses (ED60) of the barbiturates. HB-7 was superior in its action to phenobarbital and pentobarbital, manifesting higher protective indices (PI-LD50: ED50): for HB-7 PI is 4.2, for phenobarbital--3.2 and for pentobarbital--2.5, using the haemic hypoxy test. It is concluded that HB-7, i.e. 2-hydroxylamine-5-ethyl-5-sec, pentylbarbituric acid, manifests a marked protective effect in the hypoxy tests used, exceeding in some cases the effects of phenobarbital and pentobarbital.
在对白化病小鼠进行的实验中，使用以下缺氧模型：低压缺氧、缺氧、窒息性缺氧和血液性缺氧，研究了新合成的羟胺巴比妥酸盐HB - 7与苯巴比妥和戊巴比妥相比的抗缺氧作用。在应用窒息性和血液性缺氧试验时，当受试巴比妥酸盐延长小鼠存活时间时，建立了剂量 - 效应关系。后两种试验也用于确定巴比妥酸盐的平均有效剂量（ED60）。使用血液性缺氧试验时，HB - 7的作用优于苯巴比妥和戊巴比妥，表现出更高的保护指数（PI - LD50：ED50）：HB - 7的PI为4.2，苯巴比妥为3.2，戊巴比妥为2.5。得出的结论是，HB - 7，即2 - 羟胺 - 5 - 乙基 - 5 - 仲戊基巴比妥酸，在所用的缺氧试验中表现出显著的保护作用，在某些情况下超过了苯巴比妥和戊巴比妥的作用。
