Kamei C, Tsujimoto S, Tasaka K
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Japan.
J Pharmacobiodyn. 1990 Dec;13(12):772-7. doi: 10.1248/bpb1978.13.772.
Age-related changes in the acquisition and retention of memory based on the step-through active avoidance response were studied in rats and the effects of cholinergic drugs and cerebral metabolic activators on memory impairment in old rats were also tested. Six- and 12-month-old rats showed lower rates of acquisition of the active avoidance response than did 2-month-old rats. In addition, the retention of the active avoidance response in 6- and 12-month-old rats diminished rather rapidly compared with that observed in 2-month-old rats. Intraventricular injection of acetylcholine at doses of 20 and 50 ng caused a significant improvement of memory impairment in old rats. Physostigmine and arecoline also caused a significant ameliorating effect at doses of 0.02 and 0.05 mg/kg i.p. and 0.2 and 0.5 mg/kg i.p., respectively. Hopantenate calcium (100 mg/kg, p.o.), idebenone (20 and 50 mg/kg, i.p.), indeloxazine (50 mg/kg, p.o.) and DM-9384 (30 mg/kg, p.o.) also proved useful to improve memory impairment in old rats.
在大鼠中研究了基于穿梭式主动回避反应的记忆获取和保持过程中与年龄相关的变化，并且还测试了胆碱能药物和脑代谢激活剂对老年大鼠记忆损伤的影响。6个月和12个月大的大鼠主动回避反应的获取率低于2个月大的大鼠。此外，与2个月大的大鼠相比，6个月和12个月大的大鼠主动回避反应的保持能力下降得相当快。脑室内注射20和50纳克剂量的乙酰胆碱可显著改善老年大鼠的记忆损伤。毒扁豆碱和槟榔碱分别以0.02和0.05毫克/千克腹腔注射以及0.2和0.5毫克/千克腹腔注射时也产生了显著的改善作用。盐酸羟哌酯（100毫克/千克，口服）、艾地苯醌（20和50毫克/千克，腹腔注射）、茚达品（50毫克/千克，口服）和DM-9384（30毫克/千克，口服）也被证明对改善老年大鼠的记忆损伤有用。
