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[肥胖女性的胰岛素水平与动脉高血压之间无相关性]

[No correlation between insulinemic levels and arterial hypertension in obese females].

作者信息

Grugni G, Moreni G, Guzzaloni G, Ardizzi A, De Medici C, Sartorio A, Morabito F

机构信息

Centro Auxologico Italiano di Piancavallo, IRCCS, Università di Milano.

出版信息

Minerva Endocrinol. 1990 Apr-Jun;15(2):141-3.

PMID:2098656
Abstract

High blood pressure and impaired glucose tolerance are frequently associated with obesity: it has been suggested that hyperinsulinemia could represent one of the possible pathogenetic connections between obesity and systodiastolic hypertension. In order to verify this hypothesis we examined fasting and post-load insulin and glucose levels in a group of 102 obese females, 58 hypertensive and 44 normotensive. All of the subjects underwent standard OGTT in order to measure their glycemic and insulinemic levels. No differences were found between two groups, as regard age and degree of obesity; blood pressure values were significantly different (p less than 0.01). No significative differences were detected for glycemic and insulinemic levels between hypertensive and normotensive subjects. These results indicate that hyperinsulinemia is not the prominent link between obesity and arterial hypertension; the relationship between these two conditions may be indirect.

摘要

高血压和糖耐量受损常与肥胖相关

有人提出高胰岛素血症可能是肥胖与收缩舒张期高血压之间可能的发病机制联系之一。为了验证这一假设,我们检测了102名肥胖女性(58名高血压患者和44名血压正常者)的空腹及负荷后胰岛素和血糖水平。所有受试者均接受标准口服葡萄糖耐量试验(OGTT)以测量其血糖和胰岛素水平。两组在年龄和肥胖程度方面无差异;血压值有显著差异(p<0.01)。高血压组和血压正常组受试者的血糖和胰岛素水平未检测到显著差异。这些结果表明,高胰岛素血症并非肥胖与动脉高血压之间的主要联系;这两种情况之间的关系可能是间接的。

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