Passfall J, Keller F, Arntz H R
Klinikum Steglitz, Medizinische Klinik, Berlin.
Biomater Artif Cells Artif Organs. 1990;18(5):617-21. doi: 10.3109/10731199009117329.
Two patients with familial hypercholesterolemia were treated by long-term plasma exchange via an arteriovenous Cimino shunt using unselective membrane separation. Cholesterol was lowered to 40 percent (+/-3) of peak levels by each procedure. Sieving coefficient was 0.76 (+/-0.12). With a mean exchange interval of 11 days (+/-2), the peak cholesterol levels decreased from 406 mg per dl (+/-28) to 322 mg per dl (+/-27), the LDL fraction from 338 mg per dl (+/-9) to 265 mg per dl (+/-25) whereas the HDL fraction remained unchanged at 28 mg per dl (+/-4). Electrocardiographic stress testing improved in the first patient after treatment for 12 months.
两名家族性高胆固醇血症患者通过使用非选择性膜分离的动静脉Cimino分流术进行长期血浆置换治疗。每次治疗后胆固醇水平降至峰值水平的40%（±3）。筛滤系数为0.76（±0.12）。平均置换间隔为11天（±2），胆固醇峰值水平从每分升406毫克（±28）降至每分升322毫克（±27），低密度脂蛋白部分从每分升338毫克（±9）降至每分升265毫克（±25），而高密度脂蛋白部分保持不变，为每分升28毫克（±4）。第一名患者在治疗12个月后心电图应激试验有所改善。
