Postiglione A, Rubba P, Scarpato N, Iannuzzi A, Mancini M
Atherosclerosis. 1982 Feb;41(2-3):421-5. doi: 10.1016/0021-9150(82)90206-4.
Leg blood flow was measured before and 1 and 7 days after plasma exchange by venous occlusion plethysmography in a 9-year-old girl with homozygous familial hypercholesterolemia and in a 41-year-old man with heterozygous familial hypercholesterolemia. In the first patient the plasma cholesterol level was reduced from 890 mg/dl to 532 mg/dl and 666 mg/dl 1 and 7 days after plasma exchange. In the second patient plasma cholesterol decreased from 596 mg/dl to 342 mg/dl and 480 mg/dl, respectively. Leg arterial flow increased from 8.5 ml/min/l of leg volume to 19.1 and 19.5 ml/min/l in the first patient and from 6.6 ml/min/l to 18.0 and 21.8 ml/min/l in the second. No change was observed in haematocrit and total globulin concentration, which are known to play an important role in blood viscosity and flow. It is concluded that plasma exchange, possibly by decreasing plasma cholesterol concentration in patients with familial hypercholesterolemia, is associated with improved arterial flow to lower limbs and it is suggested therefore that some beneficial effect might be found also in other vascular beds.
通过静脉阻塞体积描记法，对一名患有纯合子家族性高胆固醇血症的9岁女孩和一名患有杂合子家族性高胆固醇血症的41岁男性，在进行血浆置换前以及置换后1天和7天测量腿部血流。在第一名患者中，血浆置换后1天和7天，血浆胆固醇水平分别从890毫克/分升降至532毫克/分升和666毫克/分升。在第二名患者中，血浆胆固醇分别从596毫克/分升降至342毫克/分升和480毫克/分升。第一名患者腿部动脉血流从8.5毫升/分钟/升腿部容积增加至19.1和19.5毫升/分钟/升，第二名患者则从6.6毫升/分钟/升增加至18.0和21.8毫升/分钟/升。血细胞比容和总球蛋白浓度未观察到变化，已知它们在血液粘度和血流中起重要作用。结论是，血浆置换可能通过降低家族性高胆固醇血症患者的血浆胆固醇浓度，与下肢动脉血流改善相关，因此提示在其他血管床可能也会发现一些有益效果。
