Sinitsyn V V, Metlitscaya L M, Mamontova A G, Konovalov G A, Kukharchuk V V
USSR Cardiology Research Center, Moscow.
Biomater Artif Cells Artif Organs. 1990;18(5):629-35. doi: 10.3109/10731199009117331.
Heparin-sorbent was developed in the USSR Cardiology Research Center for LDL-apheresis in patients with familial hypercholesterolemia. Clinical trials of the sorbent were started in 1985. Heparin-sorbent has a high capacity for LDL. One column (400ml) can remove 3 - 6g of LDL cholesterol, depending on the initial LDL content in the plasma. The sorbent demonstrates a high stability, it can withstand more then 75 sorbtion-desorbtion cycles with only a slight loss of the initial capacity. It means that one column can work for 1,5-2,0 years when used weekly. Heparin-sorbent is the sorbent of limited selectivity, apo-B content in eluate is 40-60% of the total protein content, but it is important that it does not bind HDL.
肝素吸附剂是苏联心脏病学研究中心为家族性高胆固醇血症患者进行低密度脂蛋白分离术而研制的。该吸附剂的临床试验始于1985年。肝素吸附剂对低密度脂蛋白具有高吸附能力。一根柱（400毫升）可去除3 - 6克低密度脂蛋白胆固醇，具体取决于血浆中初始低密度脂蛋白的含量。该吸附剂具有高稳定性，可承受超过75次吸附 - 解吸循环，初始容量仅有轻微损失。这意味着当每周使用时，一根柱可工作1.5至2.0年。肝素吸附剂是选择性有限的吸附剂，洗脱液中载脂蛋白B的含量为总蛋白含量的40 - 60%，但重要的是它不结合高密度脂蛋白。
