Homma Y, Mikami Y, Tamachi H, Nakaya N, Nakamura H, Goto Y
Metabolism. 1987 May;36(5):419-25. doi: 10.1016/0026-0495(87)90037-0.
The possibility of selective removal of low density lipoprotein (LDL) by double filtration (DF) and dextran-sulfate cellulose (DSC) column plasmapheresis in hypercholesterolemia and the acute recovery process of the subfractionated plasma lipoproteins after plasmapheresis in heterozygous familial hypercholesterolemia were investigated. Sixty-six percent of the LDL cholesterol and 42% of the HDL cholesterol were removed by 2.5 L DF plasmapheresis with the second filters having average pore diameters of 30 nm and 40 nm. Fifty-nine percent of the LDL cholesterol was removed by 2.5 L DSC column plasmapheresis, while HDL cholesterol did not change. Therefore, DSC column plasmapheresis could remove LDL much more specifically than DF plasmapheresis. VLDL increased rapidly and reached the preplasmapheresis level within four days after plasmapheresis. IDL returned to the preplasmapheresis level in 2 weeks. The LDL1 level was approximately 80% of the preplasmapheresis level on the 14th day. LDL2 reached the peak at the seventh day. HDL2 and HDL3 moved in the same manner and reached the peak on the seventh day after DF plasmapheresis.
研究了双重过滤（DF）和硫酸葡聚糖纤维素（DSC）柱式血浆置换在高胆固醇血症中选择性去除低密度脂蛋白（LDL）的可能性，以及杂合子家族性高胆固醇血症患者血浆置换后亚组分血浆脂蛋白的急性恢复过程。使用平均孔径为30nm和40nm的第二个滤器进行2.5L DF血浆置换可去除66%的LDL胆固醇和42%的HDL胆固醇。2.5L DSC柱式血浆置换可去除59%的LDL胆固醇，而HDL胆固醇无变化。因此，DSC柱式血浆置换比DF血浆置换更能特异性地去除LDL。血浆置换后，极低密度脂蛋白（VLDL）迅速增加，并在四天内达到血浆置换前水平。中间密度脂蛋白（IDL）在2周内恢复到血浆置换前水平。第14天，LDL1水平约为血浆置换前水平的80%。LDL2在第7天达到峰值。DF血浆置换后，HDL2和HDL3以相同方式变化，并在第7天达到峰值。
