Kovacs G T, Campbell J, Francis D, Hill D, Adena M A
Family Planning Association of Victoria, Australia.
Asia Oceania J Obstet Gynaecol. 1990 Dec;16(4):357-62. doi: 10.1111/j.1447-0756.1990.tb00361.x.
A double blind comparative study comparing Mucaine, Mucaine without oxethazaine, and placebo was carried out with 50 patients with symptoms of heartburn during late pregnancy. We found that the 2 active treatments were more effective than placebo for the relief of heartburn, but there was no statistically significant difference between groups for the relief of nausea and regurgitation. There was a significant difference in the percentage of days of use of each medication, with the placebo being used least frequently. Although not statistically significant, for the 3 measures for which placebo differed from the active treatments, patients showed a better response to mucaine. This suggests that the addition of oxethazaine may be of benefit. The lack of statistical significance may be due to the relatively small number of cases, and the findings are promising. No side effects were recorded for any treatment.
对50名妊娠晚期有烧心症状的患者进行了一项双盲对照研究，比较了含奥昔卡因的胃卡因、不含奥昔卡因的胃卡因和安慰剂。我们发现，两种活性治疗在缓解烧心方面比安慰剂更有效，但在缓解恶心和反流方面，各治疗组之间无统计学显著差异。每种药物的使用天数百分比存在显著差异，安慰剂使用频率最低。尽管无统计学显著差异，但在安慰剂与活性治疗存在差异的三项指标上，患者对胃卡因的反应更好。这表明添加奥昔卡因可能有益。缺乏统计学显著性可能是由于病例数相对较少，不过这些发现很有前景。任何治疗均未记录到副作用。
