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多溴联苯对虹鳟鱼单加氧作用的诱导：一项比较研究。

Induction of monooxygenation in rainbow trout by polybrominated biphenyls: a comparative study.

作者信息

Elcombe C R, Lech J J

出版信息

Environ Health Perspect. 1978 Apr;23:309-14. doi: 10.1289/ehp.7823309.

DOI:10.1289/ehp.7823309

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1637441/

Abstract

Two commercial polychlorinated biphenyl mixtures (Aroclor 1254 and Aroclor 1242) and one polybrominated biphenyl mixture (FireMaster BP-6) were examined for their abilities to induce hepatic microsomal monooxygenation in rainbow trout (Salmo gairdneri). Pretreatment of rainbow trout with Aroclors 1254 and 1242 (150 mg/kg IP) resulted in an approximate 10-fold induction of arylhydrocarbon (benzo[a]pyrene) hydroxylation, ethoxycoumarin-O-deethylation and ethoxyresorufin-O-deethylation within 7 days after injection. These enzyme activities remained elevated above control values for at least 2-3 weeks. Administration of FireMaster BP-6 (150 mg/kg IP) also resulted in an induction of several monooxygenase activities. Arylhydrocarbon (benzo[a]pyrene) hydroxylation, ethoxycoumarin-O-deethylation and ethoxyresorufin-O-deethylation were increased by 6-, 3,- and 25-fold, respectively. Only the latter two activities remained elevated two weeks post-injection. Ethylmorphine-N-demethylation was unaffected by the polyhalogenated biphenyls. Significant increases in P-450 hemoprotein were not observed after pretreatment with any of the polyhalogenated biphenyls studied.

摘要

研究了两种商业多氯联苯混合物（Aroclor 1254和Aroclor 1242）以及一种多溴联苯混合物（FireMaster BP - 6）对虹鳟鱼（Salmo gairdneri）肝脏微粒体单加氧作用的诱导能力。用Aroclors 1254和1242（150毫克/千克腹腔注射）对虹鳟鱼进行预处理后，在注射后7天内，芳烃（苯并[a]芘）羟化、乙氧基香豆素 - O - 脱乙基和乙氧基试卤灵 - O - 脱乙基的诱导倍数约为10倍。这些酶活性至少在2 - 3周内一直高于对照值。给予FireMaster BP - 6（150毫克/千克腹腔注射）也导致了几种单加氧酶活性的诱导。芳烃（苯并[a]芘）羟化、乙氧基香豆素 - O - 脱乙基和乙氧基试卤灵 - O - 脱乙基分别增加了6倍、3倍和25倍。仅后两种活性在注射后两周仍保持升高。乙基吗啡 - N - 脱甲基不受多卤联苯的影响。在用所研究的任何一种多卤联苯预处理后，未观察到P - 450血红蛋白有显著增加。