Kuhn F J, Weisse I
Department of Pharmacology, Boehringer Ingelheim KG, Ingelheim/Rhein FRG.
Lens Eye Toxic Res. 1990;7(3-4):667-76.
Using light induced retinal damage in albino rats as a model, the time of occurrence of lesions was investigated by ophthalmoscopy, electroretinography and light microscopy. Changes in the electroretinogram correlated well with histopathological lesions in the first retinal neuron. In contrast, ophthalmoscopy revealed no evidence of retinal damage even at a time, when the animals were apparently blind. It is concluded that electroretinography is an appropriate experimental tool for detection of retinal damage at a very early stage in toxicological investigation.
以白化大鼠光诱导视网膜损伤为模型，通过检眼镜检查、视网膜电图和光学显微镜研究病变发生的时间。视网膜电图的变化与第一级视网膜神经元的组织病理学损伤密切相关。相比之下，即使在动物明显失明时，检眼镜检查也未发现视网膜损伤的迹象。结论是，视网膜电图是毒理学研究中在极早期检测视网膜损伤的合适实验工具。
