Seeman N C
Department of Chemistry, New York University, NY 10003.
J Biomol Struct Dyn. 1990 Dec;8(3):573-81. doi: 10.1080/07391102.1990.10507829.
An interactive procedure has been developed to assign sequences for the design of nucleic acid secondary structure. The primary goal of the procedure is to facilitate macromolecular architecture studies through the design of branched nucleic acid mono- and oligo-junction constructs in a convenient fashion. The essential feature of the sequence-symmetry minimization algorithm employed is the treatment of short sequences as vocabulary elements whose repetition decreases control over the resulting secondary structure. Both manual and semi-automatic application of this approach are available. The design of linear nucleic acid molecules or molecules containing single-stranded loops or connectors is also possible through application of the procedure.
已经开发出一种交互式程序来为核酸二级结构设计分配序列。该程序的主要目标是以一种方便的方式通过设计分支核酸单连接和寡连接构建体来促进大分子结构研究。所采用的序列对称最小化算法的基本特征是将短序列视为词汇元素，其重复会降低对所得二级结构的控制。这种方法的手动和半自动应用都是可行的。通过应用该程序，也可以设计线性核酸分子或包含单链环或连接体的分子。
