Soto-Otero R, Mendez-Alvarez E, Otero-Cepeda J L
Department of Biochemistry and Molecular Biology, School of Medicine, University of Santiago, Spain.
J Pharm Biomed Anal. 1990;8(8-12):749-53. doi: 10.1016/0731-7085(90)80116-7.
A simple and self-explanatory program in BASIC for the statistical evaluation of potential pharmacokinetic drug interactions is described. This program, using the data (times and drug concentrations) obtained from two different populations, and with the help of graphic computing techniques, allows the determination and statistical comparison of pharmacokinetic parameters (disposition constants, transfer rate constants, area under the concentration-time curves, etc.) for one- and two-compartment open models after intravenous or extravasal administration. The program is organized in subroutines so that it can be easily modified or extended to other pharmacokinetic models by the user.
本文描述了一个用BASIC语言编写的简单易懂的程序，用于对潜在的药代动力学药物相互作用进行统计评估。该程序利用从两个不同人群获得的数据（时间和药物浓度），借助图形计算技术，能够确定并统计比较静脉注射或血管外给药后单室和双室开放模型的药代动力学参数（处置常数、转运速率常数、浓度-时间曲线下面积等）。该程序以子程序形式组织，用户可轻松修改或扩展以适用于其他药代动力学模型。
