使用含β-环糊精的流动相通过反相高效液相色谱法对手性分离后的曲普利啶对映体进行在线回收。
On-line recovery of trimeprazine enantiomers following chiral separation by reversed-phase high-performance liquid chromatography using a beta-cyclodextrin-containing mobile phase.
作者信息
Cooper A D, Jefferies T M
机构信息
School of Pharmacy and Pharmacology, University of Bath, UK.
出版信息
J Pharm Biomed Anal. 1990;8(8-12):847-51. doi: 10.1016/0731-7085(90)80131-8.
A procedure is described which allows the on-line recovery of enantiomers following semi-preparative chiral separation by RP-HPLC using beta-cyclodextrin in the mobile phase. By this method, the phenothiazine antihistamine trimeprazine (I) was resolved into its antipodes at greater than 95% optical purity at a throughput of more than 1 mg of each enantiomer per hour, using 4 mm i.d. columns. The recovered trimeprazine was found to be free from cyclodextrin.
本文描述了一种方法，该方法可在使用β-环糊精作为流动相通过反相高效液相色谱（RP-HPLC）进行半制备手性分离后在线回收对映体。通过该方法，使用内径为4 mm的色谱柱，吩噻嗪类抗组胺药曲美苄嗪（I）以大于95%的光学纯度拆分为其对映体，每小时每种对映体的通量超过1 mg。回收得到的曲美苄嗪未发现含有环糊精。
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