Maia A L, Favaretto A L, Antunes-Rodrigues J, Iazigi N, Lamano-Carvalho T L
Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1990;23(6-7):625-8.
The reproductive system of immature rats is held to be more influenced by thyroid dysfunction than that of adult animals. The effect of hypothyroidism on the spermatogenic process of the rat has not been reported previously. The objective of the present study was to investigate the spermatogenic and steroidogenic functions of pubertal hypothyroid rats. Hypothyroidism was induced by ad libitum ingestion of a 0.05% solution of propylthiouracil for 60 days, and confirmed by reduced plasma thyroxine levels in treated rats. Plasma testosterone level, the histological features of the testis and cauda epididymis and the concentration of spermatozoa stored in the cauda epididymis were unchanged by hypothyroidism.
未成熟大鼠的生殖系统被认为比成年动物的生殖系统更容易受到甲状腺功能障碍的影响。甲状腺功能减退对大鼠生精过程的影响此前尚未见报道。本研究的目的是调查青春期甲状腺功能减退大鼠的生精功能和类固醇生成功能。通过随意摄取0.05%丙硫氧嘧啶溶液60天诱导甲状腺功能减退，并通过治疗大鼠血浆甲状腺素水平降低得到证实。甲状腺功能减退并未改变血浆睾酮水平、睾丸和附睾尾部的组织学特征以及附睾尾部储存的精子浓度。
