Novelli E L, Rodrigues N L, Nagahashi A M, Sforcin J M, Ribas B O
Departamento de Química, Universidade Estadual Paulista, Brasil.
Braz J Med Biol Res. 1990;23(8):643-5.
The superoxide anion (O2-) is an extremely potent free radical which is produced during the metabolism of aerobic living cells. (O2-) may be involved in lipid peroxidation reactions which occur in a variety of systems. Cu-Zn superoxide dismutase, a metalloprotein, catalyzes the dismutation of the superoxide free radical and protects cells against superoxide damage. The ability of NiCl2 to prevent lysis of erythrocytes was tested in rats. NiCl2 administered by intratracheal route prevented hemolysis and decreased total lipids, phospholipids and bilirubin in serum. The protective effect of NiCl2 was linked to an increase in the erythrocyte activity of superoxide dismutase.
超氧阴离子（O2-）是一种极具活性的自由基，在需氧活细胞的代谢过程中产生。（O2-）可能参与多种系统中发生的脂质过氧化反应。铜锌超氧化物歧化酶是一种金属蛋白，催化超氧自由基的歧化反应，保护细胞免受超氧损伤。在大鼠中测试了氯化镍预防红细胞溶解的能力。经气管内途径给予氯化镍可预防溶血，并降低血清中的总脂质、磷脂和胆红素。氯化镍的保护作用与红细胞超氧化物歧化酶活性的增加有关。
