Balsara J J, Jadhav J H, Chandorkar A G
Psychopharmacology (Berl). 1979 Mar 29;62(1):67-9. doi: 10.1007/BF00426037.
Pretreatment with quipazine, a serotonin agonist, and clomipramine, a selective serotonin neuronal uptake blocker, was found to potentiate the cataleptic effect of haloperidol in a dose-dependent manner in rats. Pretreatment with methysergide, a serotonin antagonist, reduced the cataleptic effect of haloperidol. The results indicate that the cataleptic effect of neuroleptics depends on the balance between the dopaminergic and serotonergic systems, and that the serotonergic system exerts an inhibitory influence on the dopaminergic system.
已发现，用5-羟色胺激动剂喹哌嗪和5-羟色胺神经元摄取选择性阻滞剂氯米帕明对大鼠进行预处理，可使氟哌啶醇的僵住效应呈剂量依赖性增强。用5-羟色胺拮抗剂美西麦角进行预处理可降低氟哌啶醇的僵住效应。结果表明，抗精神病药的僵住效应取决于多巴胺能系统和5-羟色胺能系统之间的平衡，并且5-羟色胺能系统对多巴胺能系统发挥抑制作用。
