Có W, Dantas M A, Pires J G, Futuro-Neto H A
Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, Brasil.
Braz J Med Biol Res. 1990;23(9):919-22.
The medullary raphe nuclei are involved in the control of sympathetic activity during desynchronized sleep and in the modulation of nociceptive sensory inputs. To determine the participation of cholinergic and opiate mechanisms in the control of sympathetic activity, we microinjected eserine, morphine and naloxone into the nucleus raphe obscurus (NRO) of urethane-anesthetized rats. Arterial blood pressure (BP) and renal nerve activity (RN) were recorded. Eserine and morphine induced significant reductions of RN and BP, while naloxone had no effect. It is suggested that cholinergic and opiate mechanisms participate in the control of sympathetic activity by the NRO.
中缝髓核参与非同步睡眠期间交感神经活动的控制以及伤害性感觉输入的调节。为了确定胆碱能和阿片类机制在交感神经活动控制中的作用，我们向氨基甲酸乙酯麻醉的大鼠中缝隐核（NRO）微量注射了毒扁豆碱、吗啡和纳洛酮。记录动脉血压（BP）和肾神经活动（RN）。毒扁豆碱和吗啡可使RN和BP显著降低，而纳洛酮则无作用。提示胆碱能和阿片类机制参与了NRO对交感神经活动的控制。
