Yusof A P, Coote J H
Department of Physiology, Medical School, University of Birmingham, U.K.
J Auton Nerv Syst. 1988 Sep;24(1-2):71-9. doi: 10.1016/0165-1838(88)90137-3.
In chloralose/urethane anaesthetised rats multi and single fibre activity was recorded in renal sympathetic nerves and in sympathetic nerves to skeletal muscle and to the skin of the hind limb. The activity was pulse-modulated and inhibited by stimulating baroreceptors with an increase in blood pressure following i.v. phenylephrine. The study investigated the effect of stimulating medial regions of the lower brainstem on activity in these sympathetic nerves. Comparing renal nerve and skin sympathetic nerve activity two main patterns of response were seen, either an inhibition of both or excitation of both. In contrast when comparing renal nerve activity with muscle sympathetic nerve activity a third pattern was evoked from a few sites located in nucleus raphe obscurus, an inhibition of renal nerve activity and excitation of muscle sympathetic activity. The latter is the same pattern as that evoked in the cat. Unlike the cat, however, the decerebrate rat was not observed to generate this differential pattern of activity either spontaneously or following the administration of physostigmine. It is argued that the activation of cell bodies located in raphe obscurus is responsible for inducing a pattern of sympathetic activity similar to that occurring during paradoxical sleep in other animals.
在水合氯醛/乌拉坦麻醉的大鼠中，记录了肾交感神经、支配骨骼肌的交感神经以及支配后肢皮肤的交感神经中的多纤维和单纤维活动。该活动呈脉冲调制，静脉注射去氧肾上腺素后，随着血压升高刺激压力感受器可抑制该活动。本研究调查了刺激脑干下部内侧区域对这些交感神经活动的影响。比较肾神经和皮肤交感神经活动时，观察到两种主要的反应模式，即二者均被抑制或二者均被兴奋。相比之下，当比较肾神经活动与肌肉交感神经活动时，位于中缝隐核的少数部位会引发第三种模式，即肾神经活动被抑制而肌肉交感神经活动被兴奋。后者与在猫中引发的模式相同。然而，与猫不同的是，无论是在去大脑大鼠中自发观察，还是在给予毒扁豆碱后观察，均未发现产生这种差异活动模式。有人认为，位于中缝隐核的细胞体的激活负责诱导一种类似于其他动物在异相睡眠期间发生的交感神经活动模式。
