Hardy E E, Pinotti J A, Osis M J, Faúndes A
Departamento de Tocoginecologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), SP, Brasil.
Rev Saude Publica. 1990 Oct;24(5):387-93. doi: 10.1590/s0034-89101990000500006.
The purpose of the study was the identification of risk factors for benign breast diseases (BBD); 257 women with BBD diagnosed through pathological anatomy or cytology and a matched control for each were studied. Subjects were selected at The State University of Campinas Hospital and at a private clinic. To enter the study cases had to have a first diagnosis of BBD between October 1979 and August 1984. The following BBD were considered: dysplasia, fibroadenoma, cystic disease, papilloma and ductal ectasia. Reproductive variables were studied as risk factors, including menstrual ovulatory cycles. The date on which the BBD was diagnosed was defined as the index date. For controls, data were considered up to when they had reached the same age as the matched case on the occasion of her diagnosis. Nulliparity was a risk factor for BBD. First birth at or above age 30 was a protective factor. Women who had used contraceptive pills for two or more years had a significantly lower risk than those who had never used them. The number of menstrual ovulatory cycles was not found to be associated with the risk of BBD. The results obtained from the study of Brazilian women confirm some of the conclusions found in the literature, mainly those that associate some reproductive variables with the risk of BBD. A few of these variables are also confirmed as risk factors for breast cancer.
该研究的目的是确定良性乳腺疾病（BBD）的风险因素；对257名经病理解剖或细胞学诊断为BBD的女性以及与之匹配的对照进行了研究。研究对象选自坎皮纳斯州立大学医院和一家私人诊所。纳入研究的病例必须在1979年10月至1984年8月期间首次诊断为BBD。以下BBD类型被纳入研究：发育异常、纤维腺瘤、囊性疾病、乳头状瘤和导管扩张症。将生殖变量作为风险因素进行研究，包括月经排卵周期。将BBD确诊日期定义为索引日期。对于对照组，数据统计截至其年龄达到匹配病例确诊时的年龄。未生育是BBD的一个风险因素。30岁及以上初产是一个保护因素。服用避孕药两年及以上的女性患BBD的风险显著低于从未服用过避孕药的女性。未发现月经排卵周期数与BBD风险相关。对巴西女性的研究结果证实了文献中的一些结论，主要是那些将某些生殖变量与BBD风险相关联的结论。其中一些变量也被确认为乳腺癌的风险因素。
