氨基糖对埃尔斯米星A（一种DNA结合抗肿瘤抗生素）的开关功能。

Switch-function of amino sugar on elsamicin A, a DNA binding antitumor antibiotic.

作者信息

Uesugi M, Sugiura Y

机构信息

Institute for Chemical Research, Kyoto University, Japan.

出版信息

Nucleic Acids Symp Ser. 1990(22):33-4.

PMID:2101907

Abstract

There are a considerable number of DNA binding natural products equipped with amino sugar residues. The amino sugar of elsamicin A significantly takes part in DNA binding and antitumor activity. In addition, we found that an acetylation of the amino group on elsamicin A sugar portion plays an important switch-function for the activity of elsamicin A. The biological implication of this switch has been discussed.

摘要

有相当数量带有氨基糖残基的DNA结合天然产物。埃尔斯米星A的氨基糖显著参与DNA结合和抗肿瘤活性。此外，我们发现埃尔斯米星A糖部分上氨基的乙酰化对埃尔斯米星A的活性起着重要的开关作用。已经讨论了这种开关的生物学意义。