Konishi M, Sugawara K, Kofu F, Nishiyama Y, Tomita K, Miyaki T, Kawaguchi H
J Antibiot (Tokyo). 1986 Jun;39(6):784-91. doi: 10.7164/antibiotics.39.784.
New antitumor antibiotics, elsamicins A and B, were isolated from the culture broth of an unidentified actinomycete strain J907-21 (ATCC 39417). They are structurally related to chartreusin, containing the common aglycone, chartarin, but contain different sugar moieties. Elsamicin A, the major component, has an amino sugar in the molecule which makes the antibiotic much more water-soluble than chartreusin. Elsamicin A exhibits strong inhibitory activity against various murine tumors including leukemia P388, leukemia L1210, and melanoma B16 but elsamicin B which lacks the amino sugar showed only marginal activity. The potency of elsamicin A was 10-30 times more potent than that of chartreusin in terms of minimum effective dose.
新型抗肿瘤抗生素埃尔斯米星A和B是从一株未鉴定的放线菌菌株J907 - 21（ATCC 39417）的培养液中分离得到的。它们在结构上与黄绿青霉素相关，含有共同的苷元查塔林，但糖部分不同。主要成分埃尔斯米星A分子中有一个氨基糖，这使得该抗生素比黄绿青霉素的水溶性大得多。埃尔斯米星A对多种小鼠肿瘤具有强大的抑制活性，包括白血病P388、白血病L1210和黑色素瘤B16，但缺乏氨基糖的埃尔斯米星B仅表现出微弱的活性。就最小有效剂量而言，埃尔斯米星A的效力比黄绿青霉素强10至30倍。
