Broadhurst P, Kelleher C, Hughes L, Imeson J D, Raftery E B
Department of Cardiology, Northwick Park Hospital and Clinical Research Centre, U.K.
Atherosclerosis. 1990 Dec;85(2-3):169-73. doi: 10.1016/0021-9150(90)90108-u.
To asses the relationship between fibrinogen, factor VII coagulant (VIIc) activity and extent of coronary artery disease, we studied 43 white males shown to have greater than 50% stenosis of at least one major coronary artery. Thirty six had a definite history of myocardial infarction at least 3 months earlier and were classified as having 1, 2 or 3 vessel disease while 7 had 2 or 3 vessel disease, but no prior infarction. Groups were similar with regard to age, body mass index and blood pressure. In those with documented prior infarction, there was a significant relationship between the extent of atheroma and coagulation variables factor VIIc and fibrinogen. However, given a similar degree of atheroma, patients with prior infarction had significantly higher levels of factor VIIc activity compared with patients without such a history. These results corroborate those from prospective studies confirming a significant role for the coagulation system in the clinical manifestation of coronary artery disease.
为评估纤维蛋白原、凝血因子 VII 促凝活性（VIIc）与冠状动脉疾病程度之间的关系，我们研究了 43 名白人男性，这些男性被证明至少有一支主要冠状动脉狭窄超过 50%。其中 36 人至少在 3 个月前有明确的心肌梗死病史，被归类为患有单支、双支或三支血管病变，而另外 7 人患有双支或三支血管病变，但既往无梗死病史。两组在年龄、体重指数和血压方面相似。在有既往梗死记录的患者中，动脉粥样硬化程度与凝血变量因子 VIIc 和纤维蛋白原之间存在显著关系。然而，在动脉粥样硬化程度相似的情况下，有既往梗死病史的患者与无此类病史的患者相比，因子 VIIc 活性水平显著更高。这些结果证实了前瞻性研究的结果，即凝血系统在冠状动脉疾病的临床表现中起重要作用。
