Caruso C, Modica M A, Candore G, Di Giulio C, Galluzzo A, Giordano C, Di Marco P, Gebbia V, Tamone Reyes M, Citarrella P
Istituto di Patologia generale, Università di Palermo, Italy.
Boll Ist Sieroter Milan. 1990;69(1):335-8.
Lymphocytes of patients with Hodgkin's disease have a deficient production of Interleukin-2. Recently, a soluble form of the receptor for IL-2 has been demonstrated in human sera and in vitro-stimulated culture supernatants from human T lymphocytes. In the present paper we report the production of soluble IL-2R from peripheral blood mononuclear cells in H.D. The unstimulated MNC of patients released more sIL-2R than controls. No difference was observed between PHA-stimulated MNC of patients and controls. These preliminary findings suggest that soluble IL-2R may be provide a new tool for the study of immunological dysregulation in H.D.
霍奇金病患者的淋巴细胞产生白细胞介素-2的能力不足。最近，在人血清以及来自人T淋巴细胞的体外刺激培养上清液中已证实存在白细胞介素-2受体的可溶性形式。在本文中，我们报告了霍奇金病患者外周血单个核细胞中可溶性白细胞介素-2受体的产生情况。患者未受刺激的单个核细胞释放的可溶性白细胞介素-2受体比对照组更多。患者和对照组经植物血凝素刺激的单个核细胞之间未观察到差异。这些初步发现表明，可溶性白细胞介素-2受体可能为研究霍奇金病中的免疫调节异常提供一种新工具。
