Flactif M, Laï J L, Zandecki M, Bernardi F, Trillot N, Bauters F, Facon T
Laboratoire de Génétique Humaine et Pathologie Foetale, Faculté de Médecine, C.H.R.U., Lille, France.
Cancer Genet Cytogenet. 1994 Aug;76(1):10-4. doi: 10.1016/0165-4608(94)90061-2.
Two patients with multiple myeloma and an unbalanced translocation, t(1;16)(p11;p11), are reported. The fluorescence in situ hybridization (FISH) technique was used in one patient to confirm the translocation. To our knowledge, t(1;16)(p36;q13) and t(1;16)(q21;p13), but not t(1;16)(p11;p11), had been reported previously in multiple myeloma. Our results suggest that FISH is useful to characterize structural abnormalities and identify marker chromosomes in multiple myeloma where analysis with conventional cytogenetics is often difficult.
报告了2例患有多发性骨髓瘤且伴有不平衡易位t(1;16)(p11;p11)的患者。对其中1例患者使用了荧光原位杂交（FISH）技术来确认易位。据我们所知，t(1;16)(p36;q13)和t(1;16)(q21;p13)曾在多发性骨髓瘤中被报道过，但t(1;16)(p11;p11)此前未曾报道。我们的结果表明，在多发性骨髓瘤中，当常规细胞遗传学分析往往困难时，FISH有助于表征结构异常并识别标记染色体。
