Machin G A
Department of Pathology, W.C. Mackenzie Health Sciences Centre, University of Alberta, Edmonton, Canada.
Acta Genet Med Gemellol (Roma). 1990;39(4):459-71. doi: 10.1017/s0001566000003688.
Many studies of embryogenesis and fate of twin pregnancies are invalidated because zygosity is not determined definitively, or is assumed on the basis of inadequate criteria. This paper briefly reviews methods of zygosity determination. It reports published results and a new series of twins in which zygosity was determined by DNA fingerprinting. Implications for methods of prenatal diagnosis of zygosity are discussed in the context of the occasional need for intervention in twin transfusion syndrome or in twins discordant for major malformations. Definitive zygosity and placental anatomy (number of chorions and amnions) is discussed as the firm substrate for studies of normal and abnormal twin development.
许多关于双胎妊娠胚胎发生和结局的研究因合子性未明确确定或基于不充分的标准假定而无效。本文简要回顾了合子性确定的方法。报告了已发表的结果以及通过DNA指纹图谱确定合子性的一组新的双胞胎。在偶尔需要干预双胎输血综合征或双胎中存在严重畸形不一致的情况下，讨论了合子性产前诊断方法的意义。明确的合子性和胎盘解剖结构（绒毛膜和羊膜的数量）被视为正常和异常双胎发育研究的坚实基础。
