Fujii J, Seki A
J Hypertens Suppl. 1985 Apr;3(1):S19-22.
The clinical records of 1187 patients starting antihypertensive treatment during the period 1969-1979 were reviewed at the end of 1983. The annual drop-out rate was 21.0% in the first year, decreased in subsequent years and was about 1% after five years. The medication compliance of 381 patients was estimated by interview in 1980. Of all 381 patients, 243 (63.8%) reported taking 95-100% of prescribed drugs. Medication compliance was related to the frequency and timing of dosing rather than to the number of drugs. Once daily regimens had better compliance than three times daily ones, and medication compliance was greatest for morning dosing, second greatest for evening dosing, and least for dosing at noon. Repeated assessment of medication compliance on three successive years was followed by gradual improvement of compliance without any other intervention.
1983年末，对1969年至1979年期间开始接受降压治疗的1187例患者的临床记录进行了回顾。第一年的年退出率为21.0%，随后几年有所下降，五年后约为1%。1980年通过访谈对381例患者的用药依从性进行了评估。在所有381例患者中，243例（63.8%）报告服用了95%-100%的处方药。用药依从性与给药频率和时间有关，而与药物数量无关。每日一次给药方案的依从性优于每日三次给药方案，早晨给药的用药依从性最高，晚上给药次之，中午给药最低。在连续三年对用药依从性进行重复评估后，依从性在没有任何其他干预的情况下逐渐改善。
