Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University, Munich, Germany.
Acta Psychiatr Scand. 2011 Mar;123(3):228-38. doi: 10.1111/j.1600-0447.2010.01608.x. Epub 2010 Oct 4.
To examine depressive symptoms, their course during treatment, and influence on outcome.
Weekly Calgary Depression Scale for Schizophrenia ratings were performed in 249 inpatients with schizophrenia. Early response was defined as a 20% reduction in the total score of the Positive and Negative Syndrome Scale for Schizophrenia from admission to week 2, response as a 50% reduction in the total score of the Positive and Negative Syndrome Scale for Schizophrenia (PANSS) from admission to discharge and remission according to the consensus criteria.
Thirty six per cent of the patients were depressed at admission, with 23% of them still being depressed at discharge. Depressed patients scored significantly higher on the PANSS negative and general psychopathology subscore, featured more impairments in subjective well-being (P < 0.0001) and functioning (P < 0.0001). They suffered from more suicidality (P = 0.0021), and had greater insight into their illness (P = 0.0105). No significant differences were found regarding early response, response, and remission.
Patients with depressive symptoms should be monitored closely, given the burden of negative symptoms, their impairments in well-being and functioning and the threat of suicidality.
研究抑郁症状、治疗期间的病程变化及其对治疗结果的影响。
对 249 例精神分裂症住院患者每周进行一次 Calgary 抑郁量表评估。早期反应定义为从入院到第 2 周时阳性和阴性综合征量表（PANSS）总分降低 20%，反应定义为从入院到出院时 PANSS 总分降低 50%，根据共识标准判断缓解。
入院时有 36%的患者抑郁，其中 23%的患者在出院时仍有抑郁。抑郁患者的 PANSS 阴性和一般精神病学子量表评分显著更高，主观幸福感（P < 0.0001）和功能（P < 0.0001）受损更多。他们自杀风险更高（P = 0.0021），对疾病的认识更深刻（P = 0.0105）。早期反应、反应和缓解之间没有显著差异。
应密切监测有抑郁症状的患者，因为他们存在明显的阴性症状负担、幸福感和功能受损以及自杀风险。
